Folate, Folic Acid Book, Homocysteine

	Folic Acid: Everything Known About Folic Acid (Folate, Vit B9), Crucial To Everyone's Health and Longevity Written by William Bruneau Publish Date: July 1, 2007 Price $7.95 Trade Paperback Estimated 120 pages ISBN 0-9748799-1-6        LCCN: xxx
Home Quick Facts About Folic Acid Table of Contents Sample Page Sample Abstracts Scorecard Data Press Release About The Publisher Site Map To Order Links Page E-mail Us		Go To The Home Website of William Bruneau, Publisher Folic Acid is clearly written in language that is easily understood by the average reader. While solidly based on peer-reviewed research, this book is a very readable, basic primer for anyone who wants the benefits of improved health and longevity. It is our humble opinion that even health professionals could benefit greatly from referring to this absolutely up-to-date summation of all relevant published research through September, 2006. Folic acid is best known for its importance in avoiding birth defects, but research in the last few years has established that it is absolutely essential for everyone's health and well-being. It is essential for the health and proper functioning of your cells and your genes. Various scientific studies claim that anywhere from 10% to 67% of us (men, women, and children) are deficient and at risk for many deficiency diseases. Young women of child-bearing age have the greatest need and paradoxically tend to have low levels of folic acid - even after food fortification! Folic Acid contains everything known about this crucial vitamin. Fully up-to-date, it is based on the latest scientific research. This book describes what folic acid is, what it does, and explains how and why it is crucial for your health and longevity. It describes folic acid's many health benefits, and the many diseases and conditions caused by a deficiency in your body. How much to take for optimum health is described. Current research questions the adequacy of the current Recommended Daily Allowances. A central theme of this book is to help determine what is adequate - which varies significantly and is probably different for any given reader. This book lists the many ways folic acid is currently known to benefit your body, and cites an impressive list of diseases and conditions that result from not having enough of this essential vitamin, such as birth defects, many types of cancer and heart disease, stroke, and a wide range of psychological conditions(including depression, dementia, Alzheimers, schizophrenia, and epilepsy). Many others are strongly suspected like autism, brain atrophy, and vitalgo. Folic acid is thought to benefit everything from your bones to greying hair to psoriasis. This book clearly describes the evidence and the best way to avoid these risks. Homocysteine is also explained in this book - what it is and why abnormal levels have become such a concern to health professionals. There has been a tremendous amount of research in the last 10 years on this essential part of your body's biochemistry, and this book summarizes what this research has actually determined. While folic acid is the largest single determinant of your homocysteine level, this book clearly describes the other known factors that affect your level of homocysteine. Finally, due consideration is given the effects of polymorphisms (mutations) in folate biochemistry. Common mutations have become the subject of intense research due to both positive and negative effects on your health. So why buy from this website? When this book is printed we expect that you will be able to buy this book at Amazon and Barnes and Noble eventually. We have accounts with Alibris and virtually all other web bookstores which should speed distribution. Three good reasons to buy from this website: 1. You will receive this book as soon as it is printed. Customers of this website will receive this book first, without the distribution and stocking delays that you will encounter with the major booksellers. 2. Shipping is faster. While you may have to wait days for your copy to be processed and shipped from the others, we typically ship within 24 hours. 3. Shipping for this book anywhere in the U.S. is only $2.00 a copy for First Class service. No other merchant can match this! We accept all forms of payment, but feature PayPal - a secure ordering site. When ordering products from this website you can pay through PayPal Verified, which is owned and operated by EBay, and is the preferred transaction medium for most of the web. This allows you to order with confidence through the largest and most secure business site on the web. PayPal accepts your payment at no cost to you and forwards it to us without our needing to know your credit card number. Your credit and financial information is completely secure. Anyone can use PayPal’s secure services anytime for free - it costs you nothing to order! We reimburse PayPal for any charges. William Bruneau, Publisher 18001 Shafer Ranch Road, Willits, CA 95490-9626 USA fax 707-459-1925 Website: www.bbruneau.com E-Mail us: publish@bbruneau.com © Copyright 2007, William Bruneau

BMJ 2002;324:1512-1515 ( 22 June )
Folic acid, ageing, depression, and dementia
E H Reynolds, consultant neurologist.
Institute of Epileptology, King's College, London SE5 9PJ

It is becoming clear that folic acid affects mood and cognitive function, especially in older people. Edward Reynolds draws together the evidence Folic acid is important for functioning of the nervous system at all ages.1-4 In the fetus the relation between maternal folate status and the risk of neural tube defects is well established: clinical trials have shown that periconceptual preventive treatment with 400 g or higher of folic acid significantly reduces the risks of such defects.4

In neonates, infants, children, and adolescents, inborn errors of folate transport and metabolism are associated with a variety of overlapping syndromes which are influenced by age of clinical presentation. These include developmental delay, cognitive deterioration, motor and gait abnormalities, behavioural or psychiatric symptoms, seizures, signs of demyelination or failure of myelination, and vascular changes seen on magnetic resonance imaging or postmortem examination.4 Less commonly, subacute combined degeneration and peripheral neuropathy may also occur.

In adult patients presenting with megaloblastic anaemia due to folate deficiency, approximately two thirds have neuropsychiatric disorders which overlap considerably with those associated with anaemia due to vitamin B-12 deficiency. 2 5 However, depression is commoner in patients with folate deficiency, and subacute combined degeneration with peripheral neuropathy is more frequent in those with vitamin B-12 deficiency. The degree of anaemia is poorly correlated with the presence of neuropsychiatric disorders, but if these anaemias were left untreated nearly all patients would eventually develop neuropsychiatric complications.2

Over the past 35 years numerous studies have shown a high incidence of folate deficiency correlated with mental symptoms, especially depression and cognitive decline in epileptic, neurological, psychiatric, geriatric, and psychogeriatric populations. 3 4 Furthermore, recent studies in elderly people suggest a link between folic acid, homocysteine, ageing, depression, and dementia, including Alzheimer's disease and vascular disease. 4 6-9

In this paper I review the evidence relating folate deficiency to depression and dementia, especially in the ageing nervous system.

Folic acid folate homocysteine folinic acid NTD neural tube defects cancer heart disease